Comparative proteomics and glycoproteomics of plasma proteins in Indian visceral leishmaniasis
نویسندگان
چکیده
منابع مشابه
Application of Recombinant Proteins for Serodiagnosis of Visceral Leishmaniasis in Humans and Dogs
Visceral leishmaniasis (VL) is a zoonotic disease caused by leishmania species. Dogs are considered to be the main reservoir of VL. A number of methods and antigen-based assays are used for the diagnosis of leishmaniasis. However, currently available methods are mainly based on direct examination of tissues for the presence of parasites, which is highly invasive. A variety of serological tests ...
متن کاملDiagnosis and treatment of Indian visceral leishmaniasis.
LD bodies are identified by light microscopy of the specimen obtained after staining with Giemsa or Leishman stain. The sensitivity of splenic aspirate smear is more than 95% and is regarded as the gold standard for the diagnosis of Kala-azar. But the sensitivity of bone marrow smear is only about 60-85% and the procedure is painful whereas splenic aspiration carries the risk of severe hemorrha...
متن کاملManagement of visceral leishmaniasis: Indian perspective.
Diagnosis and treatment of Indian visceral leishmaniasis (VL) is extremely unsatisfactory. For diagnosis, demonstration of parasites in splenic/marrow smears remains the gold standard, though k39 rapid strip test is a useful method in regions where access to parasite demonstration is difficult. pentavalent antimony remains the mainstay for the treatment of all forms of leishmaniasis globally; h...
متن کاملOral miltefosine for Indian visceral leishmaniasis.
BACKGROUND There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral. Miltefosine is an oral agent that has been shown in small numbers of patients to have a favorable therapeutic index for Indian visceral leishmaniasis. We performed a clinical trial in India...
متن کاملVisceral Leishmaniasis in the Indian Subcontinent: Modelling Epidemiology and Control
BACKGROUND In the Indian subcontinent, about 200 million people are at risk of developing visceral leishmaniasis (VL). In 2005, the governments of India, Nepal and Bangladesh started the first regional VL elimination program with the aim to reduce the annual incidence to less than 1 per 10,000 by 2015. A mathematical model was developed to support this elimination program with basic quantificat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proteome Science
سال: 2014
ISSN: 1477-5956
DOI: 10.1186/s12953-014-0048-z